Generation of 3D Organoids of Lacrimal Glands from Human Pluripotent Stem Cells
Hayashi, R. et al. Coordinated ocular development from human iPS cells and recovery of corneal function. Nature 531376–380 (2016).
Janssen, P. & Van Bijsterveld, O. Origin and biosynthesis of human tear fluid proteins. Invest. Ophthalmol. Screw. Science. 24623–630 (1983).
Ramos-Casals, M., Tzioufas, AG, Stone, JH, Sisó, A. & Bosch, X. Treatment of primary Sjögren’s syndrome: a systematic review. JAMA 304452–460 (2010).
Pflugfelder, SC, Solomon, A. & Stern, ME The diagnosis and management of dry eye disease: a twenty-five-year review. Cornea 19644–649 (2000).
Hirayama, M. et al. Functional regeneration of the lacrimal glands by transplantation of a genetically modified organ germ. Nat. Commmon. 42497 (2013).
Shatos, MA, Haugaard-Kedstrom, L., Hodges, RR & Dartt, DA Isolation and characterization of progenitor cells from uninjured adult rat lacrimal gland. Invest. Ophthalmol. Screw. Science. 532749–2759 (2012).
Kobayashi, S. et al. Characterization of cultured murine lacrimal gland epithelial cells. Mol. Screw. 181271-1277 (2012).
Google Scholar
Bannier-Hélaouët, M. et al. Exploration of the human lacrimal gland using organoids and single cell sequencing. Cell Stem Cell 281221-1232 (2021).
Basova, L. et al. Origin and plasticity of the endogenous epithelial stem/progenitor cell lineage of the lacrimal gland. iScience 23101230 (2020).
Jeong, SY et al. Establishment of functional epithelial organoids from human lacrimal glands. Stem cell Res. The. 12247 (2021).
Hayashi, R. et al. Coordinated generation of multiple eye-like cell lines and fabrication of functional corneal epithelial cell sheets from human iPS cells. Nat. Protocol 12683–696 (2017).
Hayashi, R., Ishikawa, Y., Katayama, T., Quantock, AJ, and Nishida, K. CD200 facilitates the isolation of corneal epithelial cells derived from human pluripotent stem cells. Science. representing 816550 (2018).
Nomi, K. et al. Generation of functional conjunctival epithelium, including goblet cells, from human iPSCs. Cell representative 34108715 (2021).
Makarenkova, HP et al. FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development. Development 1272563-2572 (2000).
Yoshida, K., Nitatori, T. & Uchiyama, Y. Localization of glycosaminoglycans and CD44 in the human lacrimal gland. Camber. Histol. Cytol. 59505–513 (1996).
Chen, Z et al. FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse eye glands. Development 1412691-2701 (2014).
Shah, D. et al. Histatin-1 expression in human lacrimal epithelium. PLOS ONE 11e0148018 (2016).
Ohuchi, H. et al. FGF10 acts as a major ligand for the FGF 2 IIIb receptor in mouse multi-organ development. Biochemistry. Biophys. Res. Commmon. 277643–649 (2000).
Dean, C., Ito, M., Makarenkova, HP, Faber, SC & Lang, RA Bmp7 regulates branching morphogenesis of the lacrimal gland by promoting mesenchymal proliferation and condensation. Development 1314155–4165 (2004).
Lin, H., Liu, Y. & Yiu, S. Three-dimensional culture of potential epithelial progenitor cells in the human lacrimal gland. Transl. Screw. Science. Technology. 832 (2019).
Farmer, DT et al. miR-205 is an essential regulator of lacrimal gland development. Dev. Biol. 42712–20 (2017).
Shibata, S. et al. Laminin-directed selective differentiation of induced human pluripotent stem cells into distinct eye lineages. Cell representative 251668-1679 (2018).
Ishida, N., Hirai, S.-I. & Mita, S. Immunolocalization of aquaporin homologs in mouse lacrimal glands. Biochemistry. Biophys. Res. Commmon. 238891–895 (1997).
Tsubota, K., Hirai, S., King, LS, Agre, P. & Ishida, N. Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjögren’s syndrome. Lancet 357688–689 (2001).
Hirayama, M., Liu, Y., Kawakita, T., Shimmura, S., and Tsubota, K. Cytokeratin expression in mouse lacrimal gland germinal epithelium. Exp. Eye Res. 14654-59 (2016).
Farmer, DT et al. Define epithelial cell dynamics and lineage relationships in the developing lacrimal gland. Development 1442517-2528 (2017).
Makarenkova, HP & Dartt, DA Myoepithelial cells: their origin and function in lacrimal gland morphogenesis, homeostasis and repair. Fluent. Mol. Biol. representing 1115-123 (2015).
Tsau, C. et al. Barx2 and Fgf10 regulate ocular gland branching morphogenesis by controlling extracellular matrix remodeling. Development 1383307–3317 (2011).
Voronov, D. et al. Jtranscription factors Runx1 to 3 are expressed in the lacrimal gland epithelium and are involved in the regulation of gland morphogenesis and regeneration. Invest. Ophthalmol. Screw. Science. 543115–3125 (2013).
Hirayama, M. et al. Identification of transcription factors promoting the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells. NPJ aging mechanics. Say. 31 (2017).
Haynes, RJ, Tighe, PJ & Dua, HS Human ocular surface antimicrobial defensin peptides. Br. J. Ophthalmol. 83737–741 (1999).
Hayashi, R. et al. N-cadherin is expressed by putative stem/progenitor cells and melanocytes in the human limbal epithelial stem cell niche. Stem cells 25289–296 (2007).
Girolamo, ND et al. Localization of the p75 low affinity nerve growth factor receptor in human limbal epithelial cells. J. Cell. Mol. Med. 122799–2811 (2008).
Moroishi, T. et al. A YAP/TAZ-mediated feedback mechanism regulates Hippo pathway homeostasis. Genes Dev. 291271-1284 (2015).
Bron, AJ, Tripathi, RC and Tripathi, BJ Anatomy of Wolff’s Eye and Orbit 8th edition, 72–75 (Chapman & Hall, 1997).
Avila, MY Restoration of human tear function after injection of platelet-rich plasma. Cornea 3318-21 (2014).
Zhang, Y., Deng, C., Qian, J., Zhang, M. & Li, X. Improvement of radiation therapy-induced lacrimal gland damage by conditioned medium derived from induced pluripotent stem cells via MDK and inhibition of p38/JNK trail. Int. J.Mol. Science. 1518407–18421 (2014).
Beyazyıldız, E. et al. Efficacy of topical mesenchymal stem cell therapy in the treatment of experimental model of dry eye syndrome. Stem Cells Int. 2014250230 (2014).
Weng, J. et al. Mesenchymal stromal cell treatment alleviates dry eye in patients with chronic graft-versus-host disease. Mol. The. 202347–2354 (2012).
Okubo T et al. Fabrication of three-dimensional lacrimal gland-like tissue organoids from human pluripotent stem cells. Protocol exchange https://doi.org/10.21203/rs.3.pex-1821/v1 (2022).
Nakagawa, M. et al. A novel, efficient, power-free culture system for the derivation4 of human induced pluripotent stem cells. Science. representing 43594 (2014).
Yoshimoto, S. et al. Inhibition of Alk signaling promotes the induction of organoids derived from human salivary glands. Say. Mechanical model. 13dmm045054 (2020).
Leir, S.-H. et al. An organoid model to test the role of CFTR in human epididymal epithelium. Cell tissue Res. 381327–336 (2020).
Zheng, GX et al. Massively parallel digital transcriptional profiling of single cells. Nat. Commmon. 814049 (2017).
Stuart, T. et al. Full single-cell data integration. Cell 1771888-1902 (2019).
Trapnell, C. et al. The dynamics and regulators of cell fate decisions are revealed by the pseudotemporal ordering of individual cells. Nat. Biotechnol. 32381–386 (2014).